Nitration of Simple Heterocycles

Does Nature Prefer Heterocycles?

Does Nature Prefer Heterocycles?

Simple copper salt-catalyzed N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl halides.

Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free prima...

Photoelectron Spectroscopy of Heterocycles

The photoelectron (PE) spectra of l-(4-pyrimidyl)-2-(3-pyridyl)-ethene 1, l-(2-pyrimidyl)-2(3-pyridyl)-ethene 2, l-(4-pyridazinyl)-2-(3-pyridyl)-ethene 3, l-(3-pyridazinyl)-2-(3-pyridyl)ethene 4 and l-(2-pyrazinyl)-2-(3-pyridyl)-ethene 5 all in their trans conformations have been recorded using Hel radiation. Comparisons with the PE spectra of styrylpvridines, dipyridylethenes and diazabenzenes...

Synthesis of saturated N-heterocycles.

Saturated N-heterocycles are prevalent in biologically active molecules and are increasingly attractive scaffolds in the development of new pharmaceuticals. Unlike their aromatic counterparts, there are limited strategies for facile construction of substituted saturated N-heterocycles by convergent, predictable methods. In this Synopsis, we discuss recent advances in the synthesis of these comp...