Nipple Aspirate Fluid Cytology and the Gail Model for Breast Cancer Risk Assessment in a Screening Population

Nipple aspirate fluid cytology and the Gail model for breast cancer risk assessment in a screening population.

BACKGROUND Recent guidelines suggest that chemoprevention with tamoxifen may be appropriate for women who have a 5-year risk of breast cancer greater than 1.66% calculated using the Gail model. OBJECTIVES To determine whether nipple aspirate fluid (NAF) cytology combined with the Gail model provides breast cancer risk assessment that is superior to either method alone. METHODS Prospective o...

The role of nipple-aspirate fluid cytology in breast-cancer risk screening.

Breast cancer risk assessment in Iranian women by Gail model

  Abstract   Background: Due to the high incidence of breast cancer and the effect of its early   diagnosis on decreasing morbidity and mortality, we used the Gail model to study   breast cancer risk in Iranian women.   Methods: This study was done in a simple randomized way. Participants were 2000   Iranian women older than 35 years old. The questionnaire consisted of demographic   data such a...

Oncogenic viruses in nipple aspirate fluid: biomarkers for breast cancer risk assessment?

It would be a considerable advantage to be able to identify women at high risk for developing breast cancer to justify closer follow-up and use of multiple methods to ensure early detection. At present, the only high risk individuals identifiable with a biomarker are those 5% with a strong familial history of breast cancer. For the remaining 95% there is a lack of such biomarkers. Three indepe...

An intraductal approach to breast cancer risk assessment and screening in a diverse population

The Gail Risk model was developed based on data from Caucasian women. Little information is available regarding breast cancer risk assessment in women of other ethnicities. Our study invited asymptomatic women of color presenting for screening mammography, to be interviewed with a risk questionnaire and to undergo aspiration of nipple fluid (NAF) for cytology. The HALOR system was used to aspir...