Ninhydrin inhibition of glucose-induced insulin release
نویسندگان
چکیده
منابع مشابه
Inhibition of glucose-induced release of insulin by aldose reductase inhibitors.
ALDOSE REDUCTASE (ALDITOL: NADP oxidoreductase, EC 1.1.1.21) is the enzyme responsible for the conversion of glucose to its sugar alcohol, sorbitol. In this study, aldose reductase and a closely related enzyme, L-hexonate dehydrogenase (L-gulonate: NADP oxidoreductase, EC 1.1.1.19), were purified from rat pancreas. Glutaric acid, 2,4-dimethyl glutaric acid, 3,3-tetramethylene glutaric acid, and...
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We have previously shown that in the intact rat: (1) the inhibition of glucose-induced insulin release caused by vincristine occurred in the presence or absence of morphologic disruption of the beta-cell microtubules; and (2) vincristine, however, failed to inhibit arginine-induced insulin release, even in the presence of a marked disruption of the beta-cell microtubules. The present study furt...
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The effect of various anti-microtubular agents on alloxan stimulation and inhibition of a subsequent glucose-induced insulin release was investigated using in vitro incubation and perifusion of rat isolated islets of Langerhans. Five minute exposure of islets to alloxan (20 mg/dl) induced a transient burst of insulin release which was eliminated by the pretreatment of islets by heavy water (D20...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1977
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01236314