Nimonol from Chisocheton macrophyllus (Meliaceae) Seeds and Their Cytotoxic Activity against P-388 Leukaemia Cells

The Chisocheton genus belongs to the Meliaceae family which produces various structures and activities of compounds, such as antimalarial, antimicrobial, antitumor, anti-inflammatory, cytotoxic. This plant has 53 species that are spread in tropical sub-tropical forests, including Indonesia. plants have been known produce limonoids, namely triterpenoid compounds modified lose four terminal carbons (tetranortriterpenoids). One whose phytochemical reports still few interesting for research on limonoid content is macrophyllus. macrophyllus a tall grows rainforest northern part island Sulawesi, Indonesia, regional name ma aa, gula, pasak lingga, gending, ta suea, bekak, or pithraj tree. paper will describe compound, nimonol isolated from Nimonol molecular formula C28H36O5 group havanensin. structure was determined by spectroscopic methods UV, IR, 1D-NMR (1H-NMR, 13C-NMR, DEPT), 2D-NMR (1H-1H COSY, HMQC, HMBC), mass spectroscopy.