NIMG-60. MAGNETIC RESONANCE SPECTROSCOPY IN THE DIAGNOSTIC AND MANAGEMENT OF PATIENTS WITH BRAIN TUMORS OF GLIAL ORIGIN

Abstract PURPOSE Magnetic resonance spectroscopy (MRS) is a quantitative technique based on the chemical shift of protons that allows metabolic profile tissues to be analyzed and characterized. Standard glial tumor analysis comprises Creatine (Cr), N-acetil aspartato (NAA) Choline (Cho) metabolites, usually altered in brain pathologies (low grade -LGT-, high-grade cancer -HGT-, metastasis -MTT-, gliosis -GLS-). The aim this study analyze feasibility MRS diagnosis. METHODS prospective study, approved by Institutional Review Board, included 68 randomized patients (39 female 29 male, mean age 47 y, with confirmed histopathology). Data was acquired at Essenza Siemens 1.5T scanner, single voxel (SV) lesion (IT) healthy tissue (HT) contralateral hemisphere. A multivoxel (CS) sample obtained from ROI containing HT IT. Postprocessing done Syngo workstation, statistical analyses were performed using SPSS v25.0 p-values < 0.05 considered statistically significant. RESULTS group (by pathology) for demonstrates homogeneity. For pathological ROIs (SV, long_TE), rNAA rCho indexes (r stands Cr ratio) had p=0.003 p=0.048 respectively; however, aCho (NAA p=0.11. regions, coefficient LGT GLS: p=0.008, MTT: p=0.02, HGT p=0.008 GLS p=0.019. Meanwhile, index, HGT: p=0.005, p=0.002. Short-TE SV inhomogeneity between only ratio distinguish MTT (p=0.01) (p=0.008). Parametric map (from CS) both visually describes regions (83% 72%). CONCLUSIONS Long_TE-SV characterize lesions CS provides spatial description IT localization.