Nicotinic receptors regulate the dynamic range of dopamine release in vivo
نویسندگان
چکیده
منابع مشابه
Nicotinic receptors regulate the dynamic range of dopamine release in vivo.
Nicotinic acetylcholine receptors (nAChRs) are expressed presynaptically on dopamine axon terminals, and their activation by endogenous acetylcholine from striatal cholinergic interneurons enhances dopamine release both independently of and in concert with dopamine neuron activity. Acute nAChR inactivation is believed to enhance the contrast between low- and high-frequency dopamine cell activit...
متن کاملNonstriatal dopamine D1 receptors regulate striatal acetylcholine release in vivo.
The role of dopamine (DA) D1 receptors in the regulation of acetylcholine (ACh) release in the striatum was studied using in vivo microdialysis in freely moving rats. Systemic administration of the full D1 DA receptor agonist A-77636 (4 micromol/kg) increased striatal ACh release by 53% above the base line and decreased DA release by 33%. Local application of A-77636 (10 and 100 microM) by reve...
متن کاملCocaine inhibition of nicotinic acetylcholine receptors influences dopamine release
Nicotinic acetylcholine receptors (nAChRs) potently regulate dopamine (DA) release in the striatum and alter cocaine's ability to reinforce behaviors. Since cocaine is a weak nAChR inhibitor, we hypothesized that cocaine may alter DA release by inhibiting the nAChRs in DA terminals in the striatum and thus contribute to cocaine's reinforcing properties primarily associated with the inhibition o...
متن کاملGetting past the asterisk: the subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release.
Nicotinic acetylcholine receptors (nAChRs), despite wide distribution, do not play a major role in direct mediation of central synaptic transmission. Instead, these receptors are primarily involved in modulating the release of neurotransmitters, including glutamate, GABA, norepinephrine, dopamine, and acetylcholine itself (Role and Berg, 1996; Wonnacott, 1997). Modulation of dopamine release wi...
متن کاملAcute ethanol inhibits dopamine release in the nucleus accumbens via α6 nicotinic acetylcholine receptors.
Electrophysiology and microdialysis studies have provided compelling evidence that moderate to high ethanol concentrations enhance dopamine (DA) neurotransmission in the nucleus accumbens (NAc) through the mesolimbic DA system. However, with fast-scan cyclic voltammetry, short-term exposure to moderate to high doses of ethanol decreases evoked DA release at terminals in the NAc. The aim of this...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2014
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00269.2013