NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice
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چکیده
منابع مشابه
NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice.
Pulmonary hypertension occurs with prolonged exposure to chronic hypoxia in both adults and neonates. The Ca(2+)-dependent transcription factor, nuclear factor of activated T cells isoform c3 (NFATc3), has been implicated in chronic hypoxia-induced pulmonary arterial remodeling in adult mice. Therefore, we hypothesized that NFATc3 is required for chronic hypoxia-induced pulmonary hypertension i...
متن کاملNFATc3 is required for intermittent hypoxia-induced hypertension.
Sleep apnea, defined as intermittent respiratory arrest during sleep, is associated with increased incidence of hypertension and peripheral vascular disease. Exposure of rodents to brief periods of intermittent hypercarbia/hypoxia (H-IH) during sleep mimics the cyclical hypoxia-normoxia of sleep apnea. Endothelin-1, an upstream activator of nuclear factor of activated T cells (NFAT), is increas...
متن کاملRegulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR.
The nitric oxide/soluble guanylyl cyclase (sGC) signal transduction pathway plays an important role in smooth muscle relaxation and phenotypic regulation. However, the transcriptional regulation of sGC gene expression is largely unknown. It has been shown that sGC expression increases in pulmonary arteries from chronic hypoxia-induced pulmonary hypertensive animals. Since the transcription fact...
متن کاملRegulation of soluble guanylyl cyclase- 1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR
de Frutos S, Nitta CH, Caldwell E, Friedman J, González Bosc LV. Regulation of soluble guanylyl cyclase1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. Am J Physiol Lung Cell Mol Physiol 297: L475–L486, 2009. First published July 10, 2009; doi:10.1152/ajplung.00060.2009.—The nitric oxide/soluble guanylyl cyclase (sGC) signal transduction pathway plays an i...
متن کاملNFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.
Sleep apnea (SA) is defined as intermittent respiratory arrest during sleep and affects up to 20% of the adult population. SA is also associated with an increased incidence of hypertension and peripheral vascular disease. Exposing rodents to intermittent hypoxia during sleep mimics the cyclical hypoxia/normoxia of SA. We have previously shown that in mice and rats intermittent hypoxia induces E...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2011
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00405.2010