NF-κB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS

Regulation of CD8+ T cell responses to Toxoplasma gondii

Protective immunity to Toxoplasma gondii, an intracellular protozoan parasite, is characterized by a strongly polarized Th1-mediated immune response that is dependent on CD4+ and CD8+ T cells. In order to study the factors that influence development of CD8+ T cell responses to this parasite, a system was developed using a replication-deficient parasite that expressed the model antigen ovalbumin...

Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii.

The NF-kappaB family of transcription factors are involved in the regulation of innate and adaptive immune functions associated with resistance to infection. To assess the role of NF-kappaB(2) in the regulation of cell-mediated immunity, mice deficient in the NF-kappaB(2) gene (NF-kappaB(2)(-/-)) were challenged with the intracellular parasite Toxoplasma gondii. Resistance to this opportunistic...

Identification of a Role for NF-kB2 in the Regulation of Apoptosis and in Maintenance of T Cell-Mediated Immunity to Toxoplasma gondii

Toxoplasma gondii LCAT Primarily Contributes to Tachyzoite Egress

Egress is a crucial phase of the Toxoplasma gondii intracellular lytic cycle. This is a process that drives inflammation and is strongly associated with the pathogenesis observed during toxoplasmosis. Despite the link between this process and virulence, little is known about egress on a mechanistic or descriptive level. Previously published work has suggested that a phospholipase, lecithin-chol...

Activation-mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in mice.

Infection of mice with Toxoplasma gondii has been shown to induce a transient state of immune down-regulation. Earlier reports have demonstrated the role of cytokines, in particular IL-10, in this host response. Here evidence is presented that T. gondii, a major opportunistic pathogen of the newborn and those with AIDS, is able to induce CD4(+) T cell apoptosis in the infected murine host. We h...