NF-κB1 -94del/del ATTG polymorphic variant maintains CLL at an early, mildest stage
نویسندگان
چکیده
منابع مشابه
Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA.
Retinoic acid inducible gene I (RIG-I) senses viral RNAs and triggers innate antiviral responses through induction of type I IFNs and inflammatory cytokines. However, whether RIG-I interacts with host cellular RNA remains undetermined. Here we report that Rig-I interacts with multiple cellular mRNAs, especially Nf-κb1. Rig-I is required for NF-κB activity via regulating Nf-κb1 expression at pos...
متن کاملInvestigation of NF-κB1 and NF-κBIA Gene Polymorphism in Non-Small Cell Lung Cancer
Lung cancer is a complex, multifactorial disease which is the leading cause of cancer death in both men and women. NF-κB is a transcription factor which is known to affect the expression of more than 150 genes related to inflammation, lymphocyte activation, cell proliferation, differentiation, and apoptosis, as well as contributing to cell apoptosis and survival. However, NF-κBIA (IκBα) is the ...
متن کاملGenetic polymorphisms of NFκB1 -94 del/ins ATTG, NFκB1A 2758 A>G and SUMO rs237025 G>A in psoriasis.
BACKGROUND Nuclear factor-κB (NF-κB) and small ubiquitin-like modifier (SUMO4) are key transcription factors involved in the regulation of immune responses and apoptosis. The aim of this study is to test for the association of NF-κB and SUMO gene polymorphisms with the susceptibility and severity of psoriasis among Saudi cases. SUBJECTS AND METHODS This is a case controlled study including 85...
متن کاملAssessment of Mechatronic System Performance at an Early Design Stage
For conceptual design of electromechanical motion systems, an assessment method is formulated that supports the design of a feasible reference path generator, control system, and electromechanical plant with appropriate sensor locations, in an integrated way. This method is based on a classification of standard transfer functions, plant models, and closed-loop systems. The assessment method can...
متن کامل[Supraciliochoroidal fluid at an early stage after trabeculectomy].
PURPOSE To examine the supraciliochoroidal fluid(SCF) by ultrasound biomicroscopy(UBM) at an early stage after trabeculectomy. SUBJECTS AND METHODS Fifteen eyes without post-operative complications were examined by UBM before the operation and less than 2 weeks after trabeculectomy with mitomycin C. RESULTS SCF was detected postoperatively in 6 eyes. One eye had choroidal detachment under i...
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2021
ISSN: 1899-5276
DOI: 10.17219/acem/128764