منابع مشابه
Next Generation Phenotypic Screening: Part of a balanced strategy for accelerating drug discovery
Historically, drug discovery has employed mainly “phenotypic” approaches—often characterized by physiological observations on whole animals or organ models (Kotz 2012). Most of the first-in-class medicines, those that use a unique mechanism of action to treat a medical condition, developed before the 1980s were discovered by phenotypic Executive Summary With the advent of increasingly high thro...
متن کاملNext-Generation cDNA Screening for Oncogene and Resistance Phenotypes
There is a pressing need for methods to define the functional relevance of genetic alterations identified by next-generation sequencing of cancer specimens. We developed new approaches to efficiently construct full-length cDNA libraries from small amounts of total RNA, screen for transforming and resistance phenotypes, and deconvolute by next-generation sequencing. Using this platform, we scree...
متن کاملChallenges of using next generation sequencing in newborn screening.
Whole-genome and whole-exome sequencing for clinical applications is now an integral part of medical genetics practice. The term newborn screening refers to public health programs designed to screen newborns for various treatable metabolic conditions, by measuring levels of circulating blood metabolites. The availability and significant decrease in sequencing costs has raised the question of wh...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملNext Generation SONET / SDH Next Generation
Innovation, the lifeline to survival in the telecommunications market, has spurred the telecommunications industry to adopt next-generation SONET/SDH as the most economical and technologically feasible solution for transmitting both voice and data over carrier networks. According to Marian Stasney, a Yankee Group senior analyst, “As bandwidth demand increases or equipment becomes obsolete in me...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2016
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc-2016-0025