New therapies for von Willebrand disease

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Defining von Willebrand disease.

for repeat testing. The authors’ conclusion that it should be considered for screening patients requires further consideration and study but conceivably, this assay should improve the future of VWD diagnosis. Conflict-of-interest disclosure: P.D.J. has received research funding from Bayer, CSL Behring, and Octapharma; and honoraria for educational talks from Baxalta, CSL Behring, and Octapharma. n

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Commentary: a new classification for von Willebrand disease.

V ON WILLEBRAND DISEASE (VWD) is the most common inherited human bleeding disorder. Approximately 125 individuals per million population have symptomatic VWD, and this is roughly twice the prevalence of hemophilia A. Asymptomatic inherited defects in von Willebrand factor (VWF) function are extremely common, and are detectable in nearly 1% of unselected persons. Within the last decade dozens of...

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Von Willebrand disease

hereditary elliptocytosis and hereditary pyropoikilocytosis. Blood Cells Mol Dis 1996;22:254–8. 8 Delaunay J. The hereditary stomatocytoses: genetic disorders of the red cell membrane permeability to monovalent cations. Semin Hematol 2004;41:165–72. 9 Carella M, Stewart G, Ajetunmobi JF et al. Genomewide search for dehydrated hereditary stomatocytosis (hereditary xerocytosis): mapping of locus ...

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Von Willebrand disease

There are three major types of VWD disease. Type 1, the most frequent form, is characterized by a partial quantitative deficiency in von Willebrand factor (VWF). Type 2 is a qualitative deficiency, and Type 3 is a virtually complete deficiency. Type 2 VWD is divided into four subtypes. Type 2A includes variants with decreased platelet adhesion caused by a selective deficiency in high-molecular ...

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Von Willebrand disease

There are three major types of VWD disease. Type 1, the most frequent form, is characterized by a partial quantitative deficiency in von Willebrand factor (VWF). Type 2 is a qualitative deficiency, and Type 3 is a virtually complete deficiency. Type 2 VWD is divided into four subtypes. Type 2A includes variants with decreased platelet adhesion caused by a selective deficiency in high-molecular ...

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ژورنال

عنوان ژورنال: Hematology

سال: 2019

ISSN: 1520-4391,1520-4383

DOI: 10.1182/hematology.2019000368