New spiroindolinones bearing 5-chlorobenzothiazole moiety
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چکیده
منابع مشابه
Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety
A series of new 1,3,4-oxadiazole derivatives, 4(a-h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, (1)H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibac...
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The reported toxicities of current antitrypanosomal drugs and the emergence of drug resistant trypanosomes underscore the need for the development of new antitrypanosomal agents. We report herein the synthesis and antitrypanosomal activity of 24 new amide derivatives of 3-aminoquinoline, bearing substituted benzenesulphonamide. Nine of the new derivatives showed comparable antitrypanosomal acti...
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BACKGROUND A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a-t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate aromatic amine. The structures of the synthesized compounds were inspired from the second line antituberculosis pro-drugs. RESULTS Most of the new compounds were ...
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Synthesis and Biological Activities Evaluation of Some New 1,2,4-Triazinone Derivatives Bearing Sulfonamide Moiety
Submit Manuscript | http://medcraveonline.com infectious diseases [1-7]. These drugs were the first efficient treatment to be employed systematically for the prevention and cure of bacterial infections [8-11]. One of the first sulfonamides identified by Domagk et al. [8,9] was the red azo dye known as Prontosil [8,9]. It was active against streptococcal infection in vivo. There have been many a...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2013
ISSN: 1475-6366,1475-6374
DOI: 10.3109/14756366.2013.800058