New Silybin Scaffold for Chemical Diversification: Synthesis of Novel 23-Phosphodiester Silybin Conjugates
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چکیده
منابع مشابه
Silybin and silymarin--new effects and applications.
This article aims to review critically literature published mainly within this millennium on the new and emerging applications of silymarin, the polyphenolic fraction from the seeds of Silybum marianum and its main component silybin. Silymarin and silybin used so far mostly as hepatoprotectants were shown to have other interesting activities as e.g., anticancer and canceroprotective. These acti...
متن کاملChemistry of silybin.
Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and bette...
متن کاملSilybin-Phosphatidylcholine Complex Monograph
form, suggests phytosomal silybin might be useful against hepatitis C in chronically infected patients who do not benefit from interferon treatment.23 Ten patients who failed to measurably respond to recombinant interferon alpha 2b were studied according to a crossover, randomized, double-blind trial design. After 6-12 months of interferon withdrawal, patients were randomly assigned to receive ...
متن کاملChemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers.
Divalent or multivalent molecules often show enhanced biological activity relative to the simple monomeric units. Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by in situ and ex situ square wave voltammetry. The oxidation of monomers and dimers was similar, but adsorption onto the ele...
متن کاملEnhanced bioactivity of silybin B methylation products.
Flavonolignans from milk thistle (Silybum marianum) have been investigated for their cellular modulatory properties, including cancer chemoprevention and hepatoprotection, as an extract (silymarin), as partially purified mixtures (silibinin and isosilibinin), and as pure compounds (a series of seven isomers). One challenge with the use of these compounds in vivo is their relatively short half-l...
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ژورنال
عنوان ژورنال: Synlett
سال: 2012
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0032-1317688