New semisynthetic vinca alkaloids: chemical, biochemical and cellular studies
نویسندگان
چکیده
منابع مشابه
Vinca Alkaloids
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There ar...
متن کاملBiochemical studies with the vinca alkaloids. I. Effect on nucleic acid formation by isolated cell suspensions.
The incorporation of sodium formate-14C into nucleic acids by suspensions of rat thymus cells was inhibited in the presence of vinblastine or vinleurosine. Vincristine produced a lesser effect. The effects of vinblastine on the thymus cell system in vitro are compared with the action of the drug on thymus and other tissues under a variety of experimental conditions. The results indicate that th...
متن کاملThe Vinca Alkaloids: a New Class of Oncolytic Agents.
A phytochemical investigation of the plant Vinca ro@eaLinn. has demonstrated that a number of alkaloidal substances can be obtained with antitumon activity. Over 30 alkaloids have been obtained, of which four—vinbiastine, vinleunosine, vincnistine, and vinrosidine—are known definitely to be active. Chemically these compounds are closely related to one another and to two monomeric alkaloids,...
متن کاملDeath and Neurological Devastation From Intrathecal Vinca Alkaloids.
Inadvertent intrathecal vincristine administration causes fatalities.
متن کاملDrug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as us...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1999
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6690218