New Potent 5α- Reductase and Aromatase Inhibitors Derived from 1,2,3-Triazole Derivative
نویسندگان
چکیده
منابع مشابه
A New Era of 5α-Reductase Inhibitors for Androgenetic Alopecia
In addition to these therapies, a new oral drug dutasteride has been reported to be efficient for AGA in a large-scale (n=917) randomized controlled trial (RCT) [2]. This reagent is a 5α-reductase inhibitor similarly to finasteride. Importantly, dutasteride suppresses both type I and II 5α-reductases while finasteride significantly suppresses only type II. Therefore, dutasteride is referred as ...
متن کاملCurrent Status of 5α-Reductase Inhibitors in Prostate Disease Management
The key enzyme in the androgen synthesis and androgen receptor pathways is 5α-reductase (5-AR), which occurs as three isoenzymes. Types I and II 5-ARs the most important clinically, and two different 5-AR inhibitors (5-ARIs), finasteride and dutasteride, have been developed. Several urology associations have recommended and upgraded the use of 5-ARIs for an enlarged prostate with lower urinary ...
متن کاملQsar Studies on Human 5α-reductase Inhibitors: Unsaturated 3-carboxysteroids
Benign prostatic hyperplasia (BPH), a leading disorder of the elderly male population, is the nonmalignant enlargement of the prostate gland. It involves an increase in cell numbers in both the epithelial and stromal elements within the periurethal transition zone of the prostate (1). BPH prevalence increases with age affecting around 80% by the age of 80 years causing considerable voiding dysf...
متن کاملSymptoms of Hypogonadism Caused By 5α-Reductase Inhibitors
Hypogonadism is a disease to cause decreased energy, libido loss, body hair loss, mood depression, muscle volume reduction, and hot flashes [1-3]. 5α-reductase inhibitors (5-ARIs) are administered orally for male pattern alopecia and benign prostatic hyperplasia due to decrease of dihydrotestosterone, a potent male hormone [4]. 5-ARIs are generally known not to cause hypogonadism because 5-ARIs...
متن کاملIdiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2).
OBJECTIVE To evaluate idiopathic hirsutism etiology via molecular studies testing peripheral and local aromatase and 5α-reductase expression. DESIGN Assessment of the expression of messenger RNA (mRNA) for type 1 and 2,5α-reductase isoenzyme gene (SDR5A1, SDR5A2) and aromatase (CYP19A) in dermal papillae cells and peripheral blood mononuclear cells. SETTING University hospital. PATIENT(S)...
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules25030672