New Phenylethanoid and Other Compounds From <i>Passiflora foetida</i> L., With Their Nitric Oxide Inhibitory Activities

Seven phenolic compounds, including a new phenylethanoid, named passifoside (1), and 6 previously described syringaresinol (2), berchemol (3), threo-guaiacylglycerol (4), p-hydroxybenzaldehyde (5), 3,4,5-trimethoxyphenyl- O- β-D-glucopyranoside (6), trans- p-coumaric acid (7), were identified from the aerial parts of Passiflora foetida. Their chemical structures elucidated HR-ESI-MS NMR spectral data, comparison with literature. Compound 2 inhibited nitric oxide production in lipopolysaccharide-activated RAW264.7 cells, showing an IC 50 value 9.45 ± 0.33 µM. The other compounds showed either weak or no significant activity compared to L-NMMA, which was used as positive control.