New low-frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Max(a), a new low-frequency platelet-specific antigen localized on glycoprotein IIb, is associated with neonatal alloimmune thrombocytopenia.
We have identified a new platelet-specific alloantigen, Max(a), responsible for a typical case of neonatal alloimmune thrombocytopenic purpura. The maternal serum reacted strongly with paternal platelets in the platelet immunofluorescence test, whereas platelet alloantigen typing showed that no known human platelet antigen (HPA)-system was involved. In the monoclonal antibody (MoAb)-specific im...
متن کاملSra, a private platelet antigen on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia.
A new platelet alloantigen, Sra, is described that was defined by an alloantibody detected in the serum of a healthy mother who delivered a child with typical clinical signs of neonatal alloimmune thrombocytopenia (NAIT). The antibody reacted strongly with the child's and father's platelets, but not with platelets of the mother or with those of a highly selected panel representing all known pla...
متن کاملSr', a Private Platelet Antigen on Glycoprotein IIIa Associated With Neonatal Alloimmune Thrombocytopenia
A new platelet alloantigen, Sr", is described that was defined by an alloantibody detected in the serum of a healthy mother who delivered a child with typical clinical signs of neonatal alloimmune thrombocytopenia (NAIT). The antibody reacted strongly with the child's and father's platelets, but not with platelets of the mother or with those of a highly selected panel representing all known pla...
متن کاملSr', a Private Platelet Antigen on Glycoprotein IIIa Associated With Neonatal Alloimmune Thrombocytopenia
A new platelet alloantigen, Sr", is described that was defined by an alloantibody detected in the serum of a healthy mother who delivered a child with typical clinical signs of neonatal alloimmune thrombocytopenia (NAIT). The antibody reacted strongly with the child's and father's platelets, but not with platelets of the mother or with those of a highly selected panel representing all known pla...
متن کاملNeonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody.
An infant with severe neonatal alloimmune thrombocytopenia is described in whom an antibody directed at a new platelet-specific alloantigen, Ca (HPA-6b), is implicated. The new alloantigen is of low frequency in the population and was localized to platelet glycoprotein (GP) IIIa. Immunoprecipitation studies using murine monoclonal antibodies specific for the GP complex IIb-IIIa and GPIIIa alone...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2010
ISSN: 0041-1132,1537-2995
DOI: 10.1111/j.1537-2995.2009.02438.x