New challenges in multiple sclerosis: are oral drugs translatable into the clinic?
نویسندگان
چکیده
منابع مشابه
Challenges in developing new multiple sclerosis therapies.
In the last 15 years, we have seen the therapeutic landscape for multiple sclerosis (MS) change dramatically. From a disease that essentially had no disease-modifying therapy, we have seen the approval of several drugs that have reduced relapses and altered the progression of disability in patients with MS. However, despite these advances, there is still no cure for the disease and the need for...
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New oral drugs have considerably enriched the therapeutic armamentarium for the treatment of multiple sclerosis. This review focuses on the molecular pharmacodynamics of fingolimod, dimethyl fumarate (BG-12), laquinimod, and teriflunomide. We specifically comment on the action of these drugs at three levels: 1) the regulation of the immune system; 2) the permeability of the blood-brain barrier;...
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Multiple Sclerosis (MS) was recognized as a distinct disease involving both the brain and spinal cord and associated with disseminated demyelinating plaques (“la sclérose en plaques”) and axonal damage more than 145 years ago by French neurologist JeanMartin Charcot [1]. Since that time, the world has witnessed many remarkable discoveries. Due to progress in physics and mathematics, MRI has bec...
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While current immunomodulating drugs aim to reduce multiple sclerosis (MS) exacerbations and slow disease progression, rehabilitation aims to improve and maintain the functional abilities of patients in the face of disease progression. An increasing number of journal articles are describing the value of the many rehabilitation interventions that can be used throughout the course of the disease,...
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Introduction: Ionic channel rearrangements through the demyelinated axons or supporting media play significant role in remission of the neurological deficit in MS patients. In this study the effects of Verapamil as a calcium channel blocker on central conduction have been investigated through the evaluation of changes in P100 latency of the visual evoked potential. Method: This randomized doubl...
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ژورنال
عنوان ژورنال: Neurodegenerative Disease Management
سال: 2012
ISSN: 1758-2024,1758-2032
DOI: 10.2217/nmt.12.29