New biological trends on cell and callus growth and azadirachtin production in Azadirachta indica

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Sustainable production of azadirachtin from differentiated in vitro cell lines of neem (Azadirachta indica)

Azadirachtin has high industrial demand due to its immediate application as an ecofriendly, biodegradable biopesticide and also due to its various other significant bioactivities. To date, the only commercially feasible way to produce azadirachtin is extraction from seeds, but their availability is very limited as the tree flowers only once a year and only one-third of the fruits are collected ...

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Biological activities and medicinal properties of neem (Azadirachta indica)

Neem (Azadirachta indica A. Juss) is perhaps the most useful traditional medicinal plant in India. Each part of the neem tree has some medicinal property and is thus commercially exploitable. During the last five decades, apart from the chemistry of the neem compounds, considerable progress has been achieved regarding the biological activity and medicinal applications of neem. It is now conside...

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New antitrypanosomal tetranotriterpenoids from Azadirachta indica.

Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1-3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 an...

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Quantitative Determination of Azadirachtin in Melia indica and M. azedarach

Background: Melia indica and M. azedarach (Meliaceae) are widely used in traditional medicine. These species are considered as natural pesticides. Their major compound is azadirachtin (AZD) which is considered as the marker for quality control of these species. Objective: In the present investigation, AZD content of the leaves and fruits (comprising the whole fruit, peel, pulp and seeds) of M....

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Increased production of azadirachtin from an improved method of androgenic cultures of a medicinal tree Azadirachta indica A. Juss.

Present report is the first direct evidence of azadirachtin production in androgenic haploid cultures of Azadirachta indica, a woody medicinal tree. Anther cultures at early-late-uninucleate stage of microspores were established on MS medium with BAP (5 μM), 2,4-D (1 μM) and NAA (1 μM) containing 12% sucrose. The calli, induced, were further multiplied on 2,4-D and Kinetin media. Shoots, differ...

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ژورنال

عنوان ژورنال: 3 Biotech

سال: 2019

ISSN: 2190-572X,2190-5738

DOI: 10.1007/s13205-019-1836-z