New antiproliferative germacranolides from Carpesium divaricatum
نویسندگان
چکیده
منابع مشابه
New Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity
Eight highly oxygenated germacranolides (1-8) including four new ones (2-5) were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by NMR experiment and HRESIMS data. The absolute configuration of 1 was established by circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the n...
متن کاملThymol derivatives from Carpesium divaricatum.
Four thymol derivatives, 2,5-dimethoxythymol (1), 2-methoxythymol isobutyrate (2), 10-isobutyloxy-8,9-epoxythymolisobutyrate (3) and 10-(2-methylbutyloxy)-8,9-epoxythymolisobutyrate (4) were isolated from the aerial parts of Carpesium divaricatum. The structures were elucidated by high field 1D and 2D NMR techniques.
متن کاملNew diacylated 2-hydroxythymol derivatives from Melampodium divaricatum.
Melampodium divaricatum is a medicinal plant, which occurs in Central America. In a recent paper we reported the occurrence of acylated 2-hydroxy thymol glycosides as main constituents in this plant. This paper deals with the isolation of two new 2,5-dihydroxythymol ester derivatives. The formerly reported sesquiterpene lactone mikanokryptin was not found in our plant material.
متن کاملSesquiterpene lactones from Carpesium abrotanoides.
Phytochemical study on the ethanol extract of the aerial parts of Carpesium abrotanoides led to the isolation of two new sesquiterpene lactones, carabrolactone A (1) and carabrolactone B (2). Their structures were elucidated on the basis of extensive spectroscopic analysis.
متن کامل2-Pyrrolidineacetic Acid and Pyrrolizidine Alkaloids from Melampodium divaricatum.
The atypical, non-toxic pyrrolizidine alkaloid tussilagin and its isomers have been found in only a few plants of the Asteraceae (Roeder et al., 1981,1984; Passreiter et al., 1992; Roeder et al., 1993; Sener and Etgun, 1996; Wernery et al., 1997; Passreiter, 1998). Their possible biosynthetic precursor pyrrolidine-2-acetic acid and its methylester were isolated and identi"ed together with the p...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2019
ISSN: 2046-2069
DOI: 10.1039/c9ra00478e