منابع مشابه
Neutrophil Extracellular Traps Go Viral
Neutrophils are the most numerous immune cells. Their importance as the first line of defense against bacterial and fungal pathogens is well described. In contrast, the role of neutrophils in controlling viral infections is less clear. Bacterial and fungal pathogens can stimulate neutrophils extracellular traps (NETs) in a process called NETosis. Although NETosis has previously been described a...
متن کاملNeutrophil extracellular traps
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.
متن کاملNeutrophil extracellular traps
Coming soon to a doctor’s surgery near you? Hopes placed on the sequencing of ‘the’ human genome and the subsequent identification of many single-nucleotide polymorphisms (SNPs) have turned out to be misguided, as the causes of common diseases like cancer and heart disease have proven too complex to be addressed with simple SNP searches. Also, large-scale genomic differences like copy number va...
متن کاملNicotine induces neutrophil extracellular traps.
NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same time contribute to tissue damage and excessive inflammation. Nicotine is a major toxic agent and has been associated with exacerbated inflammatory diseases. The current study aimed at investigating the role of nicotine, the addictive component of tobacco and electronic cigarettes, on triggering NET formation. We r...
متن کاملNeutrophil Extracellular Traps and Microcrystals
Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage. Interestingly, the ability of different microcrystals to induce NET formation has been recently described. Microcrystals are insoluble crystals with a size of 1-100 micrometers th...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2016
ISSN: 1664-3224
DOI: 10.3389/fimmu.2016.00366