Neutrophil extracellular trap formation in theStreptococcus suis-infected cerebrospinal fluid compartment
نویسندگان
چکیده
منابع مشابه
Mechanical ventilation induces neutrophil extracellular trap formation.
BACKGROUND Mechanical ventilation can injure the lung and induce a proinflammatory state; such ventilator-induced lung injury (VILI) is associated with neutrophil influx. Neutrophils release DNA and granular proteins as cytotoxic neutrophil extracellular traps (NETs). The authors hypothesized that NETs were produced in a VILI model and may contribute to injury. METHODS In a two-hit lipopolysa...
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Neutrophil extracellular traps (NETs) can be released in the vasculature. In addition to trapping microbes, they promote inflammatory and thrombotic diseases. Considering that P-selectin induces prothrombotic and proinflammatory signaling, we studied the role of this selectin in NET formation. NET formation (NETosis) was induced by thrombin-activated platelets rosetting with neutrophils and was...
متن کاملNADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.
NADPH oxidase is a crucial enzyme in antimicrobial host defense and in regulating inflammation. Chronic granulomatous disease (CGD) is an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive oxidant intermediates. Aspergillus species are ubiquitous, filamentous fungi, which can cause invasive aspergillosis, a major cause of morbidity and mortality in C...
متن کاملRecombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro
The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NETosis). Human peripheral blood neutrophils and platelets were co-incubated with or without LPS (0.2 μg/ml) in the presence and absence of rTM (2 μg/ml). NETosis was confirmed by immunostain...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2016
ISSN: 1462-5814
DOI: 10.1111/cmi.12649