Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRP ) from the cell surface
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چکیده
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Is Sudden Hearing Loss Associated with Atherosclerosis?
Introduction: Sudden sensorineural hearing-loss (SSNHL) patients constitute approximately 2–3% of referrals to ear, nose and throat (ENT) clinics. Several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. In this research the atherosclerotic changes and their known risk factors are studied in SSNHL patients. Materials and ...
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CD47, a cell surface transmembrane Ig superfamily member, is an extracellular ligand for signal regulatory protein (SIRPalpha). Interactions between CD47 and SIRPalpha regulate many important immune cell functions including neutrophil (PMN) transmigration. Here we report identification of a novel function-blocking peptide, CERVIGTGWVRC, that structurally mimics an epitope on CD47 and binds to S...
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Interaction of SIRP with its ligand, CD47, regulates leukocyte functions, including transmigration, phagocytosis, oxidative burst, and cytokine secretion. Recent progress has provided significant insights into the structural details of the distal IgV domain (D1) of SIRP . However, the structural roles of proximal IgC domains (D2 and D3) have been largely unstudied. The high degree of conservati...
متن کاملCD 47 - Signal Regulatory Protein a ( SIRP a ) Regulates Fc g and Complement Receptor – mediated Phagocytosis
In autoimmune hemolytic anemia (AIHA), circulating red blood cells (RBCs) opsonized with autoantibody are recognized by macrophage Fc g and complement receptors. This triggers phagocytosis and elimination of RBCs from the circulation by splenic macrophages. We recently found that CD47 on unopsonized RBCs binds macrophage signal regulatory protein a (SIRP a ), generating a negative signal that p...
متن کاملDown-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation.
We have established an RNase protection method to quantify the expression of mRNA for the human protein kinase C (PK-C) isoforms alpha, beta 1, beta 2, and gamma. This was used to investigate whether each isoform is differentially expressed during the differentiation of hematopoietic cells. Myeloid and lymphoid cells express PK-C alpha, beta 1, and beta 2 mRNAs in various proportions. PK-C gamm...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2012
ISSN: 0741-5400
DOI: 10.1189/jlb.1110637