Neurotrophic Factors Promote and Enhance Locomotor Recovery in Untrained Spinalized Cats

Recovery in Untrained Spinalized Cats Neurotrophic Factors Promote and Enhance Locomotor

Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats.

In spinal cats, locomotor recovery without rehabilitation is limited, but weight-bearing stepping returns with treadmill training. We studied whether neurotrophins administered to the injury site also restores locomotion in untrained spinal cats and whether combining both neurotrophins and training further improves recovery. Ordinary rat fibroblasts or a mixture of fibroblasts secreting brain-d...

Could Neurotrophins Replace Treadmill Training as Locomotor Therapy Following Spinal Cord Injury? Focus on “Neurotrophic Factors Promote and Enhance Locomotor Recovery in Untrained Spinalized Cats”

How to repair the injured spinal cord is a question that scientists have struggled with for decades. The answer is of course still a mystery. But ask people on the street for their opinion and they will likely offer something like “stem cells” as the solution. I find it amusing (and honestly, a bit annoying) that family and friends continue to ask me if there is anything new with stem cells. My...

Could neurotrophins replace treadmill training as locomotor therapy following spinal cord injury? Focus on "neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats".

How to repair the injured spinal cord is a question that scientists have struggled with for decades. The answer is of course still a mystery. But ask people on the street for their opinion and they will likely offer something like “stem cells” as the solution. I find it amusing (and honestly, a bit annoying) that family and friends continue to ask me if there is anything new with stem cells. My...

Nonlocomotor and locomotor hindlimb responses evoked by electrical microstimulation of the lumbar cord in spinalized cats.

As a preliminary step to using intraspinal microstimulation (ISMS) for rehabilitation purposes, the distribution of various types of hindlimb responses evoked by ISMS in spinal cats (T(13)) is described. The responses to ISMS applied through a single electrode was assessed, before and after an intravenous injection of clonidine (noradrenergic agonist), using kinematics and electromyographic rec...