Neurotoxicity Associated with a High-Affinity GD2 CAR—Response
نویسندگان
چکیده
منابع مشابه
Identification and Tumour-Binding Properties of a Peptide with High Affinity to the Disialoganglioside GD2
Neuroectodermal tumours are characterized by aberrant processing of disialogangliosides concomitant with high expression of GD2 or GD3 on cell surfaces. Antibodies targeting GD2 are already in clinical use for therapy of neuroblastoma, a solid tumour of early childhood. Here, we set out to identify peptides with high affinity to human disialoganglioside GD2. To this end, we performed a combined...
متن کاملPreclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex.
Bispecific antibodies (BsAb) have proven to be useful targeting vectors for pretargeted radioimmunotherapy (PRIT). We sought to overcome key PRIT limitations such as high renal radiation exposure and immunogenicity (e.g., of streptavidin-antibody fusions), to advance clinical translation of this PRIT strategy for diasialoganglioside GD2-positive [GD2(+)] tumors. For this purpose, an IgG-scFv Bs...
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ژورنال
عنوان ژورنال: Cancer Immunology Research
سال: 2018
ISSN: 2326-6066,2326-6074
DOI: 10.1158/2326-6066.cir-18-0090