منابع مشابه
A diphosphopyridine nucleotidase and its protein inhibitor from Mycobacterium butyricum.
The diphosphopyridine nucleotidase exchange reaction, whereby isonicotinic acid hydrazide can replace nicotinamide in the DPN’ molecule, was demonstrated by Zatman el al. (1). Since this reaction provided a possible explanation for the growth inhibition of Mycobacteria by isonicotinic acid hydrazide, methods for measuring DPN in Mywbacteria were investigated. It was found that acetone powder ex...
متن کاملDiphosphopyridine Nucleotidase as an Extracellular Product of Streptococcal Growth and Its Possible Relationship to Leukotoxicity
Among 170 streptococcal strains, there were encountered 98 that yielded culture supernates which caused splitting of diphosphopyridine nucleotide (DPN). All of the latter belonged to Group A, C, or G. Release of DPNase accompanied the growth of diverse antigenic types of Group A streptococci, and data on the frequency of DPNase-producing strains for certain types are given. In contrast, culture...
متن کاملSerum inhibition of streptococcal diphosphopyridine nucleotidase in uncomplicated streptococcal pharyngitis and in rheumatic fever.
One of the recently described extracellular products of Group A streptococci is diphosphopyridine nucleotidase (DPNase) (1). This enzyme has received attention as a substance of possible importance in the etiology of either rheumatic fever or glomerulonephritis because a) it was isolated from cardiotoxic fractions of supernates of broth cultures of Group A streptococci (2, 3) and b) almost all ...
متن کاملNeutralizing Antibodies to Streptococcal Diphosphopyridine Nucleotidase in the Serum of Experimental Animals and Human Beings
Specific neutralizing antibodies directed against streptococcal DPNase were induced experimentally in rabbits and guinea pigs by the injection of partially purified preparations of the enzyme. Similar antibodies capable of inhibiting the biological activity of the enzyme were found to occur naturally in the serum of a very high percentage of human beings, and the titer of these antibodies often...
متن کاملDiphosphopyridine nucleotide pyrophosphatase.
Enzymatic splitting of diphosphopyridine nucleotide (DPN)’ by microorganisms, plants, and animal tissues has been known for many years, but the precise nature of this reaction is not well understood (1). Ohlmeyer (2) first observed that adenylic acid (5-phosphoadenosine) appeared when DPN was incubated with yeast maceration juice. Later Heiwinkel (3) identified adenylic acid as a product of the...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1951
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55952-4