Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment

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Neuropsychiatric Symptoms in Mild Cognitive Impairment.

OBJECTIVE Neuropsychiatric symptoms (NPS) may be the first manifestation of an underlying neurocognitive disorder. We undertook a review to provide an update on the epidemiology and etiological mechanisms of NPS that occur in mild cognitive impairment (MCI) and just before the onset of MCI. We discuss common clinical presentations and the implications for diagnosis and care. METHOD The author...

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Neuropsychiatric symptoms in Mild Cognitive Impairment

Materials and methods A total of 30 subjects, aged more than 60 years old, with either MCI (n = 16) or control group (n = 14) were studied. Neuropsychiatric symptoms (NPS) were assessed using the Neuropsychiatric Inventory scale(NPI). Individual subscores of the 10 NPI symptoms and total NPI scores were compared between the MCI patients and control patients. We identified the prevalence of the ...

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Identification of mild cognitive impairment disease using brain functional connectivity and graph analysis in fMRI data

Background: Early diagnosis of patients in the early stages of Alzheimer's, known as mild cognitive impairment, is of great importance in the treatment of this disease. If a patient can be diagnosed at this stage, it is possible to treat or delay Alzheimer's disease. Resting-state functional magnetic resonance imaging (fMRI) is very common in the process of diagnosing Alzheimer's disease. In th...

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Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study.

CONTEXT Little is known about the population-based prevalence of neuropsychiatric symptoms in mild cognitive impairment (MCI). OBJECTIVE To estimate the prevalence of neuropsychiatric symptoms in MCI and normal cognitive aging in a defined population. DESIGN Cross-sectional study derived from an ongoing population-based prospective cohort study. SETTING The Mayo Clinic Study of Aging. P...

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Obesity and Co-morbid Conditions Are Associated with Specific Neuropsychiatric Symptoms in Mild Cognitive Impairment

Background: Neuropsychiatric symptoms (NPSs) in MCI, and midlife obesity increase the likelihood of developing Alzheimer's disease. It is unknown whether obesity or related health conditions modify the risk of NPS or severity of cognitive impairment in MCI. Methods: One hundred and thirteen subjects with MCI were assessed near the time of MCI diagnosis. The sample was divided by BMI and related...

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ژورنال

عنوان ژورنال: Journal of Alzheimer's Disease

سال: 2015

ISSN: 1387-2877,1875-8908

DOI: 10.3233/jad-150017