Neuropsichiatric Manifestations of Systemic Lupus Erythematosus: Diagnosis and Treatment Approach

Abstract Neuropsychiatric involvement in systemic lupus erythematosus includes heterogeneous manifestations involving both the central and peripheral nervous system. A major issue clinical evaluation is attribution of neuropsychiatric symptoms to erithematosus. Antiphospholipid antibodies, immune complex, microangiopathy, early accelerated arteriosclerosis are factors that have main role pathogenesis There no neurological specific erithematosus, but they can also occur very commonly general population. Lesions system be focal or diffuse may due erithematosus itself (primary lesions), it caused by other diseases disbalances. Therapy depends on nature pathological process (dominant inflammation thrombosis). If result an inflammatory neurotoxic presence increased activity therapy glycocorticoids independently combination with immunosuppressives. Focal syndrome antiphospholipid antibodies positivity should treated anticoagulant and/or antiplatelet therapy. In addition, control classical cardiovascular risk factors, stop smoking, treatment hydroxychloroquine recommended.