Neuroprotective effect of Hypericum perforatum extract against Aluminum-maltolate induced toxicity in SH-SY5Y cells

Alzheimer's disease is multi-component neurodegenerative disorder. Oxidative stress disrupts regular functioning of metabolism in early-onset disease. It causes Tau phosphorylation, formation neurofibrillary tangle and neuron reduction. Due to intense binding phosphorylated amino acids aluminum, it induces self-assembly deposition high degree cytoskeletal proteins, such as microtubule neurofilament-associated proteins. In this study, aimed consider the antioxidant potential Hypericum perforatum extract against neurotoxicity caused by Aluminum-maltolate (Al(mal)3) its effects on APP gene expression. Four different groups were determined observe impact H. extract. After incubation cells for 24 hours, only medium was placed first group control. 500 μM Al(mal)3 added second cells. 20 μg mL-1 third group. For fourth group, added. While increased total status levels SH-SY5Y human neuroblastoma cells, significantly inhibited induced oxidative stress. On other hand, decreased expression depending toxicity According these results, To determine synergistic antagonistic content important examine their specific together with hyperforin, which a phytochemical produced some members plant genus Hypericum, discover new therapeutic agents neurodegeneration.