Neuroprotective and detrimental effects of astrocytes on amyloid plaque formation

In Alzheimer’s disease (AD) brains, reactive astrocytes and microglia are frequently seen around amyloid plaques. The functions of have been extensively studied, such as the neuroprotective barrier they form to prevent plaque growth their release inflammatory cytokines. However, less well known. Here I review ongoing research on astrocytic Recent studies suggest that play an important role in downregulating Aβ production through cholesterol reducing deposition uptake clearance. Astrocytes also interact with clusterin C3 pathways, possibly altering fibril formation phagocytosis. On other hand, contribute elevated glutamate GABA levels, potentially causing excitotoxicity accelerating cognitive decline. Finally, two possible therapeutic treatments, ceftriaxone selegiline, for alleviating AD pathology by targeting astrocyte functions. Given crucial complex roles AD, a better understand would greater understanding progression uncover new targets.