Neuroprotection by Docosahexaenoic Acid in Brain Injury
نویسندگان
چکیده
منابع مشابه
Maternal docosahexaenoic acid-enriched diet prevents neonatal brain injury.
Hypoxic-ischemic encephalopathy due to neonatal asphyxia is one of the most important causes of delayed neurological development. Prolonged neuronal apoptosis plays an important role in the processes contributing to neuronal degeneration. Docosahexaenoic acid (DHA), a major component of brain membrane phospholipids, prevents neuronal cell apoptosis and plays an important role as an anti-oxidant...
متن کاملDocosahexaenoic acid confers enduring neuroprotection in experimental stroke
Recently we demonstrated that docosahexaenoic acid (DHA) is highly neuroprotective when animals were allowed to survive during one week. This study was conducted to establish whether the neuroprotection induced by DHA persists with chronic survival. Sprague-Dawley rats underwent 2h of middle cerebral artery occlusion (MCAo) and treated with DHA or saline at 3h after MCAo. Animals received neuro...
متن کاملRethinking Neuroprotection in Severe Traumatic Brain Injury: Toward Bedside Neuroprotection
Neuroprotection after traumatic brain injury (TBI) is an important goal pursued strenuously in the last 30 years. The acute cerebral injury triggers a cascade of biochemical events that may worsen the integrity, function, and connectivity of the brain cells and decrease the chance of functional recovery. A number of molecules acting against this deleterious cascade have been tested in the exper...
متن کاملDocosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection.
BACKGROUND AND PURPOSE High-dose human albumin therapy is strongly neuroprotective in models of brain ischemia and trauma and is currently being studied in a pilot-phase clinical stroke trial. Among its actions in ischemia, albumin induces the systemic mobilization of n-3 polyunsaturated fatty acids and may help to replenish polyunsaturated fatty acids lost from neural membranes. METHODS We c...
متن کاملDietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury.
BACKGROUND Although various strategies for prevention of brain disease have been implemented, no substance has been found to be advantageous for prophylaxis against brain injury. OBJECTIVE While previous work in our laboratory and others have shown positive effects using the omega-3 fatty acid docosahexaenoic acid (DHA) in post-injury treatment following traumatic and ischemic insults, we wis...
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ژورنال
عنوان ژورنال: Military Medicine
سال: 2014
ISSN: 0026-4075,1930-613X
DOI: 10.7205/milmed-d-14-00162