Neurophysiological Subtypes of Depressive Disorders

Background: the clinical polymorphism of depressive disorders, together with available data on different responses patients to treatment, motivate modern neuroscience search for models that can explain such heterogeneity. Objective: identify neurophysiological subtypes disorders. Patients and methods: 189 moderate depression in structure a episode (n = 42), recurrent 102) bipolar affective disorders 45); 56 healthy subjects. Clinical-psychopathological, psychometric, statistical research methods were used work. The results: help coherent EEG analysis, it is possible at least 6 disorder, which characterize various branches pathogenesis pathology, go beyond currently accepted nomenclature. selected determined by profi les dysfunctional interaction cortical zones alpha, beta gamma ranges EEG. Subtype 1 was characterized decrease relative norm imaginary alpha-coherence between right parietal left central, anterior temporal, as well temporal leads (P4-C3, P4-F7, P4-F8) explained part depressions, leading role played violations promotion positive suppression negative affect. 2 — an increase beta-2-imaginary-coherence frontal hemispheres, central cortex (F3-F4; F3-C4) its (C4-C3), terms this subtype persistent hedonic response associated picture atypical depression. 3 (F4-F3) hemisphere correlated severity rumination. 4 frontal, (F8-F4 F8-C4), depressions developed against background avoidance personality disorder. 5 coherence parietal, occipital (F3-P3 C3-O1), outwardly oriented utilitarian style thinking (alexithymia). beta-1 (C3-F8), phobic hypochondriacal Such biological typology seems new promising searching specifi c types and, accordingly, reaching differentiated therapeutic recommendations.