Neuropathological Features of Covid-19

Epidemiological Features of Covid-19 Epidemic in Hamadan Province, Finding of a Ten-Month Period

Background and Objectives: The aim of this study was to investigate the epidemiological characteristics of patients with Covid-19 in Hamadan Province.   Materials and Methods: In this descriptive cross-sectional study, demographic and epidemiological data of all people who presented to hospitals in Hamadan Province from February 2019 to December 2020 were extracted using two checklists. Data ...

Clinical Features and Outcomes of Suspected and Confirmed COVID-19 Patients in Saveh, Iran, 2020

 Background and purpose: The outbreak of Coronavirus Disease 2019 (COVID-19) pneumonia is a major threat to global public health because it is very contagious and spreads quickly by human-to-human transmission. This study aimed to investigate the clinical characteristics and outcome of patients infected with COVID-19 in Saveh, Iran. Materials and methods: A descriptive-analytical study was con...

COVID-19 in Nursing Homes: The Problematic Management of Residents Without Positive COVID-19 RT-PCR

Neuropathological features of Alzheimer's disease in non-demented parkinsonian patients.

Two patients with levodopa-responsive Parkinson's syndrome had numerous cortical and striatal senile plaques and some neurofibrillary tangles at necropsy. In addition neurons in the pars compacta of the substantia nigra were severely depleted but there were no Lewy bodies or other neuropathological changes to account for parkinsonism. Neither patient was demented. These pathological findings ha...

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

Mutations in the stress granule protein T-cell restricted intracellular antigen 1 (TIA1) were recently shown to cause amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD). Here, we provide detailed clinical and neuropathological descriptions of nine cases with TIA1 mutations, together with comparisons to sporadic ALS (sALS) and ALS due to repeat expansions in C9orf7...