Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging
نویسندگان
چکیده
منابع مشابه
Gray and white matter brain abnormalities in first-episode schizophrenia inferred from magnetization transfer imaging.
BACKGROUND Neuroimaging studies suggest that schizophrenia is associated with gray and possibly white matter changes. It is unclear whether these changes are present at illness onset or which brain structures are selectively affected. New imaging methods such as magnetization transfer imaging may be more sensitive than conventional volumetric imaging to the subtle structural brain changes in sc...
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IMPORTANCE Abnormalities in neural activity and cerebral bioenergetics have been observed in schizophrenia (SZ). Further defining energy metabolism anomalies would provide crucial information about molecular mechanisms underlying SZ and may be valuable for developing novel treatment strategies. OBJECTIVE To investigate cerebral bioenergetics in SZ via measurement of creatine kinase activity u...
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BACKGROUND AND PURPOSE In the concept of ischemic penumbra, the volume of salvaged penumbra is considered as the volume of FLAIR normalization on follow-up MRI compared with early diffusion and perfusion abnormalities. Using magnetization transfer imaging, very sensitive to macromolecular disruption, we investigated whether FLAIR normalization was a good marker for tissue full recovery. METHO...
متن کاملComparing free water imaging and magnetization transfer measurements in schizophrenia.
Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white matter in schizophrenia. However, popular DWI-derived measures such as fractional anisotropy (FA) may be sensitive to many types of pathologies, and thus the interpretation of reported differences in these measures remains difficult. Combining DWI with magnetization transfer ratio (MTR) - a putati...
متن کاملSHORT REPORT Neuropathological abnormalities of the corpus callosum in schizophrenia: a diVusion tensor imaging study
Objectives—DiVusion tensor imaging (DTI), a technique capable of examining water diVusion in diVerent tissues and the organisation of white matter tracts, was used to investigate the neuropathology of the corpus callosum in vivo in patients with schizophrenia. Methods—DiVusion tensor imaging was performed in 20 schizophrenic patients and 25 healthy controls. Two complementary measures, mean diV...
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ژورنال
عنوان ژورنال: Brain
سال: 2001
ISSN: 1460-2156
DOI: 10.1093/brain/124.5.882