Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia
نویسندگان
چکیده
منابع مشابه
Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia.
It has been generally assumed that the cell body (soma) of a neuron, which contains the nucleus, is mainly responsible for synthesis of macromolecules and has a limited role in cell-to-cell communication. Using sniffer patch recordings, we show here that electrical stimulation of dorsal root ganglion (DRG) neurons elicits robust vesicular ATP release from their somata. The rate of release event...
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BACKGROUND Adenosine 5'-triphosphate (ATP) has a ubiquitous role in metabolism and a major role in pain responses after tissue injury. We investigated the changes in basal and KCl-evoked ATP release from rat dorsal root ganglia (DRG) after peripheral neuropathy induction by unilateral sciatic nerve entrapment (SNE). RESULTS After SNE, rats develop long-lasting decreases in ipsilateral hindpaw...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0611048104