منابع مشابه
Neuronal or Glial Progeny Regional Differences in Radial Glia Fate
The precursor function of the ubiquitous glial cell type in the developing central nervous system (CNS), the radial glia, is largely unknown. Using Cre/loxP in vivo fate mapping studies, we found that radial glia generate virtually all cortical projection neurons but not the interneurons originating in the ventral telencephalon. In contrast to the cerebral cortex, few neurons in the basal gangl...
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Long-awaited evidence for in vivo functions of the major neuronal microtubule associated proteins indicates that they are directly involved in neurite extension. Companion evidence reveals an intrinsic role for glial intermediate filaments in glial cell extension along neurites and for neurofilaments in establishing axonal caliber. New fluorescence and photoactivation experiments require a re-t...
متن کاملNeuronal and glial cell biology.
us&y a cellular neurobiologist struggles to link findings made in simple cellular systems to the problems of the neuron. It is therefore gratifying when the flow is reversed and discoveries in neurons are seminal to the understanding of cell biology in general. This has been especially true for the past year in the field of membrane traffic in the nerve terminal. As reviewed by Martin (pp 626-6...
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The Glial cells missing transcription factor is necessary and sufficient to induce glial-cell fates in the Drosophila embryonic nervous system. A study by Chotard et al. in this issue of Neuron reveals that this "master regulator" of glial cell fate specification is also required (gasp!) to generate neurons.
متن کاملNeuronal and glial cell biology
Kang Shen is an investigator in the Howard Hughes Medical Institute and an associate professor in the Department of Biology at Stanford University. His laboratory studies synapse formation in C. elegans and mammals with a focus on synaptic target recognition, presynaptic assembly, and axonal transport. Introduction The wiring of the nervous system is arguably the most challenging question in de...
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ژورنال
عنوان ژورنال: Neuron
سال: 2003
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(03)00116-8