Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex
نویسندگان
چکیده
منابع مشابه
The contribution of demyelination to axonal loss in multiple sclerosis.
The traditional notion that multiple sclerosis is a primary demyelinating disease has led to a plaque-centred view of both aetiology and the pathogenesis of disease progression. The presence of axonal loss has received increasing recognition. However, the relative roles of demyelination and axonal loss have not been fully clarified in multiple sclerosis nor have their possible interrelationship...
متن کاملMacular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis.
BACKGROUND Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons). OBJECTIVE To determine how inner vs outer macular volumes relate to peripapillary RNFL thickness and visual function in multiple sclerosis (MS) and to examine how these patterns differ among e...
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H. H. Kitzler, J. Su, M. Zeineh, S. C. Deoni, C. Harper-Little, A. Leung, M. Kremenchutzky, and B. K. Rutt Dept. of Neuroradiology, Technische Universitaet Dresden, Dresden, SN, Germany, Department of Radiology, Stanford University, Palo Alto, CA, United States, Department of Engineering, Brown University, Providence, RI, United States, Imaging Laboratories, Robarts Research Institute, London, ...
متن کاملDemyelination versus remyelination in progressive multiple sclerosis.
The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with ...
متن کاملInflammatory cortical demyelination in early multiple sclerosis.
BACKGROUND Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonanc...
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ژورنال
عنوان ژورنال: Neuropathology and Applied Neurobiology
سال: 2017
ISSN: 0305-1846
DOI: 10.1111/nan.12405