Neuronal itaconate restricts viral infection
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چکیده
منابع مشابه
Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection. However, the role of astrocytes in innate immune responses of the BBB during viral infection of the CNS remains to be fully elucidated. Here, we have demonstrated that type I IFNAR signaling in ast...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2019
ISSN: 1474-1733,1474-1741
DOI: 10.1038/s41577-019-0121-z