منابع مشابه
Cytosolic free calcium and cell death during metabolic inhibition in a neuronal cell line.
Elevated free cytosolic Ca2+ (Ca2+i) has been implicated as a mechanism of hypoxic neuronal death. The calcium hypothesis postulates that the basic metabolic response to hypoxic ATP depletion is a toxic increase in free cytosolic Ca2+i in all cell types. This inherent response then creates the environment in which subsequent derangements of Ca2+i may occur, for example, from glutamate excitotox...
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penheim, 1991; Burek and Oppenheim, 1998). Although Neurons may die at many different developmental stages some of these hypotheses have received experimental and for many different reasons. As in other tissues, difsupport in individual systems, none seems to be generferent stimuli produce quite different morphological ally applicable. Indeed, it remains to be demonstrated that manifestations o...
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The calcium ionophore ionomycin induces apoptosis-like events in the human embryonic kidney (HEK) cell line at early times. Plasma membrane blebbing, mitochondrial depolarization, externalization of phosphatidylserine and nuclear permeability changes can all be observed within 15 min of treatment. However, there is no activation of caspases or chromatin condensation. Expression of a fusion prot...
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Although Ca(2+) signals are necessary for cell communication and survival, abnormal cellular Ca(2+) load can trigger different cell death programs. Ca(2+) mediates cell death by activating proteases (ie, calpains), by reinforcing signals leading to caspase activation or by triggering other catabolic processes mediated by lipases and nucleases. Failure in the clearance of excitatory amino acid i...
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AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca(2+) and Zn(2+). Ca(2+) permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases an...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)38171-5