منابع مشابه
Mitochondrial dysfunction in mouse trisomy 16 brain.
Mitochondrial function in the brain of mouse trisomy 16, an animal model of Down syndrome with accelerated neuron death, was studied in isolated cortex mitochondria. Using an oxygen-sensitive Clarke electrode, a selective 16% decrease in respiration was detected with the Complex I substrates malate and glutamate but not with the Complex II substrate succinate. Western blotting revealed a 20% de...
متن کاملCerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture.
Trisomy 21 (Down syndrome) is associated with a high incidence of Alzheimer disease and with deficits in cholinergic function in humans. We used the trisomy 16 (Ts16) mouse model for Down syndrome to identify the cellular basis for the cholinergic dysfunction. Cholinergic neurons and cerebral cortical astroglia, obtained separately from Ts16 mouse fetuses and their euploid littermates, were cul...
متن کاملDefects in Thymocyte Differentiation and Thymocyte- Stromal Interactions in the Trisomy 16 Mouse
We have examined fetal thymic development in the trisomy 16 (Ts16) mouse, which is considered to be a model for human trisomy 21, or Down Syndrome. The Ts16 thymus contains 10 to 20% of the number of lymphocytes found in a normal thymus at a comparable stage. Expression of thymocyte differentiation markers (Thy-1, CD5, CD8, CD4, CD3, and HSA) is severely affected in Ts16 fetuses aged 14-18 gest...
متن کاملTetrasomy 16 in the mouse: a more severe condition than the corresponding trisomy.
Although an understanding of the phenotypic similarities and differences between individuals trisomic and tetrasomic for the same chromosome or chromosome segment is of considerable theoretical interest with regard to the relationship of the phenotypic features of aneuploid states to changes in the dosage of specific genes, the data obtainable from human cases of tetrasomy do not permit firm co...
متن کاملExamination of Alzheimer-Type Neurodegeneration in Mouse Trisomy 16 Neurons Maintained by Transplantation
Down’s syndrome (DS, trisomy 21) results from an extra copy of human chromosome 21. Included in the phenotype of this syndrome is the development of neurofibrillary tangles and neuritic plaques that are characteristic of Alzheimer’s disease (AD) (Wisniewski KE et al., Ann Neurol 1985; 17: 278-282). The hippocampus is an early and critical site of this pathology. Animal models would greatly aid ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2001
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.1999.721769.x