Neurofibromatosis Clinical Trials—REiNS Collaboration 2020 Recommendations

Neurofibromatosis (NF) type 1 (NF1), NF 2 (NF2), and schwannomatosis are genetic tumor predisposition syndromes with a wide variety of clinical manifestations. Effective medical treatments for these conditions remain limited. Since its founding in 2011, the Response Evaluation Schwannomatosis (REiNS) International Collaboration has worked to develop standardized, practical, clinically meaningful outcome measures trials conditions. Two previous supplements published Neurology ® 20131 20162 set forth recommendations that summarized table.