Neurodegenerative disease: Body-building for small molecules

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

Phenotypic drug discovery requires billions of cells for high-throughput screening (HTS) campaigns. Because up to several million different small molecules will be tested in a single HTS campaign, even small variability within the cell populations for screening could easily invalidate an entire campaign. Neurodegenerative assays are particularly challenging because neurons are post-mitotic and ...

Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders.

In recent years, an increasing number of studies have been published, focusing on the potential therapeutic use of small catalytic agents with strong biological properties. So far, most of these works have only regarded specific clinical fields, such as oncology, infectivology and general pathology, in particular with respect to the treatment of significant inflammatory processes. However, inte...

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases

Neurodegenerative diseases (NDs) are among the most feared of the disorders that afflict humankind for the lack of specific diagnostic tests and effective treatments. Understanding the molecular, cellular, biochemical changes of NDs may hold therapeutic promise against debilitating central nerve system (CNS) disorders. In the present review, we summarized the clinical presentations and biology ...

“ Small Molecules for Understanding Life & Managing Disease ”

Histone deacetylase (HDAC) inhibition is a clinically validated cancer treatment strategy which targets the components of the cellular epigenetic machinery. Despite promises in preclinical studies, HDAC inhibitors (HDACi) have been less efficacious in treating solid tumors. To address this problem, we envisioned the design of HDACi equipped with secondary pharmacophores to facilitate selective ...

INTERACTION OF PROTEINS WITH SMALL MOLECULES