Neuroanatomy and Neurochemistry of Mouse Cornea

Neuroanatomy and Neurochemistry of Mouse Cornea

PURPOSE To investigate the entire nerve architecture and content of the two main sensory neuropeptides in mouse cornea to determine if it is a good model with similarities to human corneal innervation. METHODS Mice aged 1 to 24 weeks were used. The corneas were stained with neuronal-class βIII-tubulin, calcitonin gene-related peptide (CGRP), and substance P (SP) antibodies; whole-mount images...

Choosing delayed rewards: perspectives from learning theory, neurochemistry, and neuroanatomy

4 . DELAYED REINFORCEMENT IN CHOICE...........................................................................6 4.1 . UTILITY THEORY AS AN APPROACH TO NORMAL AND PATHOLOGICAL CHOICE IN ANIMALS..........6 4.2 . CHOICE WITHIN THE BRAIN: ‘TOP-DOWN’ AND ‘BOTTOM-UP’ APPROACHES................................8 4.3 . TEMPORAL DISCOUNTING AND IMPULSIVE CHOICE ..............................................

Selective immunolesions of cholinergic neurons in mice: effects on neuroanatomy, neurochemistry, and behavior.

The ability to selectively lesion mouse basal forebrain cholinergic neurons would permit experimental examination of interactions between cholinergic functional loss and genetic factors associated with neurodegenerative disease. We developed a selective toxin for mouse basal forebrain cholinergic neurons by conjugating saporin (SAP), a ribosome-inactivating protein, to a rat monoclonal antibody...

The In Vivo Functional Neuroanatomy and Neurochemistry of Vibrotactile Processing PhD Thesis

Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond.

Despite more than 2 decades of neuroimaging investigations, there is currently insufficient evidence to fully understand the neurobiological substrate of auditory hallucinations (AH). However, some progress has been made with imaging studies in patients with AH consistently reporting altered structure and function in speech and language, sensory, and nonsensory regions. This report provides an ...