Neural stem cells in inflammatory CNS diseases: mechanisms and therapy
نویسندگان
چکیده
منابع مشابه
Neural stem cell therapy in neurological diseases
Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural s...
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Recent advances in stem cell research, including the selective expansion of neural stem cells (NSCs) in vitro, the induction of particular neural cells from embryonic stem cells in vitro, the identification of NSCs or NSC-like cells in the adult brain and the detection of neurogenesis in the adult brain (adult neurogenesis), have laid the groundwork for the development of novel therapies aimed ...
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Stem cells have been investigated for their therapeutic potential in spinal cord injury (SCI), stroke and animal models of amyotrophic lateral sclerosis (ALS). We compared human mesenchymal stem cells (MSC) from bone marrow, a conditionally immortalized human stem cell line from fetal spinal cord (SPC-01) and human induced pluripotent stem cell-derived neural precursors (iPS-NPs) for their capa...
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Background: Pregnenolone as a precursor of steroid hormones, can be effect on inflammatory condition to maintain immune homeostasis. The previous study shows that pregnenolone levels are reduced in neuro inflammatory disease, which emphasizes its role in neuroprotection and nerve regeneration and its anti-inflammatory role So the aim of this study try to investigated effect of pregnenolone on ...
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Recent studies on human inflammatory bowel diseases (IBD) have brought our attention to continued epithelial injury and impaired epithelial regeneration as their key pathophysiological features. In order to develop a novel approach for the treatment of IBD, it is important to understand the ordered process of epithelial repair and the pivotal roles for the epithelial stem cells in this process....
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2005
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2005.tb00357.x