Neural Stem Cell Grafting in an Animal Model of Chronic Temporal Lobe Epilepsy
نویسندگان
چکیده
منابع مشابه
P 111: Use of Stem Cell Therapy for Treatment of Temporal Lobe Epilepsy (TLE)
Epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. Excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. One of the most common and difficult to treat types of epilepsy is Temporal Lobe Epilepsy (TLE), which results from hippocampal sclerosis. Cu...
متن کاملCircadian control of neural excitability in an animal model of temporal lobe epilepsy.
We provide experimental evidence for the emerging imbalance in the firing activity of two distinct classes (type 1 and type 2) of population spikes recorded from the hippocampal area CA1 in an animal model of temporal lobe epilepsy. We show that during the latent period of epileptogenesis following status epilepticus inducing brain injury, there is a sustained increase in the firing rate of typ...
متن کاملHippocampal neurogenesis and neural stem cells in temporal lobe epilepsy.
Virtually all mammals, including humans, exhibit neurogenesis throughout life in the hippocampus, a learning and memory center in the brain. Numerous studies in animal models imply that hippocampal neurogenesis is important for functions such as learning, memory, and mood. Interestingly, hippocampal neurogenesis is very sensitive to physiological and pathological stimuli. Certain pathological s...
متن کامل[Developing a new animal model of temporal lobe epilepsy].
Epilepsy affects 1-2 % of the population. For 30 % of these patients, their syndrome will be refractory to medical treatment. To improve our understanding and treatment of the epilepsies, we need to develop clinically relevant animal models. As temporal lobe epilepsy is often preceded by prolonged febrile seizures and in our population associated with a focal cortical dysplasia, we hypothesised...
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ژورنال
عنوان ژورنال: Current Protocols in Stem Cell Biology
سال: 2011
ISSN: 1941-7322,1938-8969
DOI: 10.1002/9780470151808.sc02d07s18