Neural response to trauma?related and trauma?unrelated negative stimuli in remitted and persistent pediatric post?traumatic stress disorder

Introduction Most youths who suffer from post-traumatic stress disorder (PTSD) lose their diagnosis in the first 1–2 years. However, there are few studies on this brain mechanism, and heterogeneity of findings is partially due to different stimuli applied mixed trauma history. Therefore, use trauma-related/unrelated study remittance mechanism earthquake-induced PTSD could advance our knowledge inspire future treatment. Methods Thirteen with PTSD, 18 remitted participants, control participants underwent functional magnetic resonance imaging (fMRI), while viewing trauma-related pictures, trauma-unrelated negative scrambled pictures. Results Under condition, neural activity left hippocampus group was between two other groups. exhibited higher right middle occipital gyrus than controls. The showed parahippocampal lingual under condition no significant difference found group. Conclusion status-related differences mainly reflected hyperactivity be an endophenotype for PTSD.