Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
نویسندگان
چکیده
منابع مشابه
Does cognitive reserve shape cognitive decline?
OBJECTIVE Cognitive reserve is associated with a lower risk of dementia, but the extent to which it shapes cognitive aging trajectories remains unclear. Our objective is to examine the impact of 3 markers of reserve from different points in the life course on cognitive function and decline in late adulthood. METHODS Data are from 5,234 men and 2,220 women, mean age 56 years (standard deviatio...
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Dopamine and some other neuromodulators are thought to act by volumetric signaling (i.e., gradient diffusion of neurotransmitter to receptors beyond a synaptic release site). In this issue, Paspalas and Goldman-Rakic outline such a signaling pathway involving the D5 dopamine receptor. They used immunogold labeling and electron microscopy in pyramidal neurons of monkey prefrontal cortex. Specifi...
متن کاملExploring the neural basis of cognitive reserve.
There is epidemiologic and imaging evidence for the presence of cognitive reserve, but the neurophysiologic substrate of CR has not been established. In order to test the hypothesis that CR is related to aspects of neural processing, we used fMRI to image 19 healthy young adults while they performed a nonverbal recognition test. There were two task conditions. A low demand condition required en...
متن کاملBrain reserve and cognitive decline: a non-parametric systematic review.
BACKGROUND A previous companion paper to this report (Valenzuela and Sachdev, Psychological Medicine 2006, 36, 441-454) suggests a link between behavioural brain reserve and incident dementia; however, the issues of covariate control and ascertainment bias were not directly addressed. Our aim was to quantitatively review an independent set of longitudinal studies of cognitive change in order to...
متن کاملTHE EFFECT OF LOCUS CERULEUS LESIONING ON TONIC AND PHASIC PAIN
Bulbospinal noradrenergic pathways are shown to have an important role in descending inhibition of pain sensation. Locus ceruleus (LC), as a rich noradrenergic nucleus in the brain stem which has projections into the dorsal horn of the spinal cord, was evaluated for antinociceptive activity by using tonic and phasic pain models in the rat. LC-lesioned rats demonstrated moderate increase in ...
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ژورنال
عنوان ژورنال: Neurology
سال: 2013
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e3182897103