Neural regulation in tooth regeneration of Ambystoma mexicanum

The influence of aminopterin on limb regeneration in Ambystoma mexicanum.

Regeneration of Limb Joints in the Axolotl (Ambystoma mexicanum)

In spite of numerous investigations of regenerating salamander limbs, little attention has been paid to the details of how joints are reformed. An understanding of the process and mechanisms of joint regeneration in this model system for tetrapod limb regeneration would provide insights into developing novel therapies for inducing joint regeneration in humans. To this end, we have used the axol...

Neurotrophic regulation of epidermal dedifferentiation during wound healing and limb regeneration in the axolotl (Ambystoma mexicanum).

Adult urodeles (salamanders) are unique in their ability to regenerate complex organs perfectly. The recently developed Accessory Limb Model (ALM) in the axolotl provides an opportunity to identify and characterize the essential signaling events that control the early steps in limb regeneration. The ALM demonstrates that limb regeneration progresses in a stepwise fashion that is dependent on si...

Identification of Genes Involved in Limb Regeneration in the Axolotl Ambystoma mexicanum

The Mexican axolotl, Ambystoma mexicanum, is a unique vertebrate species which has amazing powers of limb regeneration. In the present study we have used a Subtractive Amplification approach to identify genes which are activated and overexpressed during the limb regeneration process. In our initial studies, we have found that levels of expression of 11 genes are increased during the limb regene...

A staging system for forelimb regeneration in the axolotl, Ambystoma mexicanum.

A staging system has been devised for normal regeneration from the upper arm in the mature axolotl. It consists of seven externally definable stages: (1) Wound healing (WH): (2) Dedifferentiation (DD); (3) Early bud (EB); (4) Medium bud (MB); (5) Late bud (LB); (6) Palette (Pal), and (7) Digital outgrowth (DO). Serial histological sections of 38 regenerating limbs were used to correlate gross s...