Neural Precursor Cells Cultured at Physiologically Relevant Oxygen Tensions Have a Survival Advantage Following Transplantation
نویسندگان
چکیده
منابع مشابه
Survival and behaviour of ammocoetes at low oxygen tensions.
There have been comparatively few studies on respiration in the ammocoete larva of lampreys. For this reason an investigation of the oxygen consumption of ammocoetes, living in burrows in a simulated natural substrate, was made to gain some knowledge of the oxygen requirements of these animals (Hill & Potter, 1970). In the present study we have attempted to relate aspects of the respiratory phy...
متن کاملExpression of neurodevelopmental markers by cultured porcine neural precursor cells.
Despite the increasing importance of the pig as a large animal model, little is known about porcine neural precursor cells. To evaluate the markers expressed by these cells, brains were dissected from 60-day fetuses, enzymatically dissociated, and grown in the presence of epidermal growth factor, basic fibroblast growth factor, and platelet-derived growth factor. Porcine neural precursors could...
متن کاملLong-term fate of neural precursor cells following transplantation into developing and adult CNS.
Successful strategies for transplantation of neural precursor cells for replacement of lost or dysfunctional CNS cells require long-term survival of grafted cells and integration with the host system, potentially for the life of the recipient. It is also important to demonstrate that transplants do not result in adverse outcomes. Few studies have examined the long-term properties of transplante...
متن کاملHypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
Human embryonic stem (hES) cells are routinely cultured under atmospheric, 20% oxygen tensions but are derived from embryos which reside in a 3-5% oxygen (hypoxic) environment. Maintenance of oxygen homeostasis is critical to ensure sufficient levels for oxygen-dependent processes. This study investigates the importance of specific hypoxia inducible factors (HIFs) in regulating the hypoxic resp...
متن کاملThermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures.
A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37-42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: STEM CELLS Translational Medicine
سال: 2013
ISSN: 2157-6564
DOI: 10.5966/sctm.2012-0144