Neucleotide sequence of bullfrog pro-opiomelanocortin cDNA
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چکیده
منابع مشابه
Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA.
Polyadenylated RNA was isolated from a mouse pituitary tumor cell line (AtT-20/D16v) which synthesizes and secretes adrenocorticotropic hormone and beta-endorphin. The RNA was used to construct a cDNA library by a double linker technique and the library was screened for pro-opiomelanocortin (POMC) sequences. One recombinant plasmid, pMKSU16, contained a 923-base pair insert comprising the entir...
متن کاملNucleotide sequence of cloned cDNA for pro-opiomelanocortin in the amphibian Xenopus laevis.
The function of alpha-melanocyte-stimulating hormone (alpha-MSH) is not known in mammals. It is well-established in the amphibian Xenopus laevis in which alpha-MSH mediates the process of adaptation to a dark background. The amino acid sequence of this hormone is, however, not known in amphibians. In order to determine the primary structure of the precursor protein for alpha-MSH, which in mamma...
متن کاملComplete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin.
A glycopeptide isolated in relatively large amounts from human pituitary glands was completely purified, and its sequence was determined. The primary sequence represents the NH2-terminal 76 amino acid residues of pro-opiomelanocortin (POMC). This important secretory product of POMC was shown to possess an interesting aldosterone-stimulating activity on a human adrenal aldosteronoma. It is O-gly...
متن کاملNucleotide sequence of pre-pro-von Willebrand factor cDNA.
This cDNA sequence is complete except for approximately 150 bp of 5' untranslated and lOObp of 3 untranslated sequence. The whole sequence was derived on both strands. An upstream stop codon in the major open reading frame is shown by asterisks. Potential sites for N-linked glycosylation are underlined. The sites of cleavage of signal peptide and vWF pro-polypeptide (1) are indicated by arrows....
متن کاملPro-opiomelanocortin Peptides in Mouse Pituitary Cells*
Pro-opiomelanocortin (POMC) is glycosylated and proteolytically cleaved to produce a number of smaller peptide hormones including adrenocorticotropic hormone (ACTH) and endorphin in mammalian pituitary and the mouse pituitary cell Line AtT-20/DI6,. When glycosylation of POMC is inhibited in AtT-20 cells with the drug tunicamycin, a 26,000-dalton protein appears in place of the glycosylated 29,0...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1989
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/17.14.5843